Harold D. Kim
Assistant Professor
Ph.D., Stanford University, 2004
Office: Boggs B-83
Office Phone:
Lab: Boggs B-66
Lab Phone:
EMail: harold.kim [at] physics.gatech.edu
Harold Kim Lab Website
■ Research ■
We use physical means and quantitative models to understand the workings of biological systems ranging from molecules to cells. In particular, our research interests are centered around transcriptional activation in eukaryotic cells where DNA is highly condensed (chromatin) in a tiny subcellular structure (nucleus).
■ Publications ■
- H.D. Kim*, T. Shay*, E.K. O'Shea, and A. Regev, “Transcriptional Regulatory Circuits: Predicting Numbers from Alphabets,” Science, vol. 325, 2009, p. 429.
- H.D. Kim and E.K. O’Shea, “A quantitative model of transcription factor–activated gene expression,” Nature Structural & Molecular Biology, vol. 15, 2008, p. 1192.
- S. Uemura, M. Dorywalska, T.H. Lee, H.D. Kim, J.D. Puglisi, and S. Chu, “Peptide bond formation destabilizes Shine–Dalgarno interaction on the ribosome,” Nature, vol. 446, 2007, p. 454.
- T.H. Lee, S.C. Blanchard, H.D. Kim, J.D. Puglisi, and S. Chu, “The role of fluctuations in tRNA selection by the ribosome,” Proceedings of the National Academy of Sciences, vol. 104, 2007, p. 13661.
- H.D. Kim, J.D. Puglisi, and S. Chu, “Fluctuations of transfer RNAs between classical and hybrid states,” Biophysical Journal, vol. 93, 2007, pp. 3575–3582.
- U. Mohanty, A. Spasic, H.D. Kim, and S. Chu, “Ion Atmosphere of Three-Way Junction Nucleic Acid” J. Phys. Chem. B, vol. 109, 2005, pp. 21369–21374.
- M. Dorywalska, S.C. Blanchard, R.L. Gonzalez, H.D. Kim, S. Chu, and J.D. Puglisi, “Site-specific labeling of the ribosome for single-molecule spectroscopy,” Nucleic Acids Research, vol. 33, 2005, p. 182.
- S.C. Blanchard*, H.D. Kim*, R.L. Gonzalez*, J.D. Puglisi, and S. Chu, “tRNA dynamics on the ribosome during translation,” Proceedings of the National Academy of Sciences, vol. 101, 2004, p. 12893.
- S.C. Blanchard, R.L. Gonzalez*, H.D. Kim*, S. Chu, and J.D. Puglisi, “tRNA selection and kinetic proofreading in translation,” Nature structural & molecular biology, vol. 11, 2004, pp. 1008–1014.
- X. Zhuang, H. Kim, M.J. Pereira, H.P. Babcock, N.G. Walter, and S. Chu, “Correlating structural dynamics and function in single ribozyme molecules,” Science, vol. 296, 2002, p. 1473.
- H.D. Kim, G.U. Nienhaus, T. Ha, J.W. Orr, J.R. Williamson, and S. Chu, “Mg2+-dependent conformational change of RNA studied by fluorescence correlation and FRET on immobilized single molecules,” Proceedings of the National Academy of Sciences, vol. 99, 2002, p. 4284.
- X. Zhuang, T. Ha, H.D. Kim, T. Centner, S. Labeit, and S. Chu, “Fluorescence quenching: A tool for single-molecule protein-folding study,” Proceedings of the National Academy of Sciences, vol. 97, 2000, p. 14241.
- T. Ha, X. Zhuang, H.D. Kim, J.W. Orr, J.R. Williamson, and S. Chu, “Ligand-induced conformational changes observed in single RNA molecules,” Proceedings of the National Academy of Sciences of the United States, vol. 96, 1999, p. 9077.
■ Biography ■
PhD, Applied Physics, Stanford University
BS, Physics, KAIST