Dynamics and Regulation of Sec-Facilitated Protein Translocation and Integral Membrane Protein Insertion

The Sec translocon is a central component of cellular pathways for protein translocation and membrane integration.  Using both atomistic and coarse-grained molecular simulations, we investigate the conformational landscape of the translocon and explore the role of peptide substrates in the regulation of the translocation and integration pathways.   Implications of these results for the regulation of Sec-mediated pathways for protein translocation and membrane integration are discussed.

 

Event Details

Date/Time:

  • Date: 
    Tuesday, October 8, 2013 - 11:00am

Location:
MoSE Room 3201A