Molecular Biomechanics: The Deformation and Dynamics of Proteins and Nucleic Acids Gang Bao Biomedical Engineering, Georgia Institute of Technology With the advent of molecular biology and biophysics during the last decade or so, molecule biomechanics has emerged as a new field. In addition to addressing basic science issues in DNA dynamics, protein conformational changes, molecular motors, and protein-protein/protein-DNA interactions, molecular biomechanics can help solve problems in biotechnology and medicine, including the development of novel biosensors and protein chips. In this talk, I will discuss some of the research projects in my group, especially the work on DNA dynamics, protein hinge motion, molecular beacons and protein chips. I will also explore the connection between mechanics and biochemistry, and discuss the issues and challenges in developing molecular biomechanics and bioengineering.